DNA-42 Clinicalift Serum™

Repair the Biology. Reverse the Damage. Reclaim Your Skin.

A physician-formulated regenerative serum that visibly lifts, densifies, and restores skin not by masking the signs of aging, but by activating the biological pathways responsible for structural renewal.

Long before "longevity skincare" became a trend, Clark's Botanicals was studying the cellular resilience mechanisms of the Amalfi Coast, one of the world's most biodiverse and protected coastal ecosystems, and translating them into measurable pathways for human skin. In this uniquely protected environment, botanicals and marine organisms thrive under constant environmental stress. DNA-42 captures the science behind that survival.

DNA-42 Clinicalift™ Serum is the first expression of Amalfi Born Biotechnology™, and the first topical serum to combine plant-derived exosome delivery technology with a Vegan PDRN regenerative complex. Together, they ensure that repair signals reach the dermal cells where visible renewal truly begins. Polydeoxyribonucleotide (PDRN) has long been studied in regenerative dermatology historically sourced from animal tissue.

DNA-42 advances this science entirely: our plant-derived Vegan PDRN complex, drawn from rice and barley, is clinically shown to outperform legacy animal-derived formulations in collagen synthesis, fibroblast vitality, and epidermal renewal. This is not an ethical compromise. It is a clinically superior evolution. The result is a serum that works with your skin's biology not against it. Skin appears smoother, clearer, and more luminous not because something has been erased, but because the skin's own structural vitality has been rebuilt.

Your skin's been keeping score. DNA-42 is here to settle it.

Apply 3-5 drops to cleansed face AM and/or PM. Press gently into skin using fingertips, working outward from the center of the face. Allow to absorb fully before layering moisturizer or SPF.

For optimal results, use consistently through a complete 42-day renewal cycle. Do not interrupt the cycle, visible structural change requires the full biological timeline.

Pro Tip: Unlike retinol or strong acid treatments, DNA-42 works with your skin's biology rather than against it. There is no downtime, no cycling, and no irritation phase. You can layer it with your existing routine from day one. Sensitive skin approved.

• Visibly lifts and firms contours across a complete 42-day renewal cycle
• Stimulates collagen synthesis and supports extracellular matrix reinforcement
• Reduces visible wrinkle depth and softens expression lines
• Increases dermal density and improves structural integrity from within
• Restores skin vitality: smoothness, clarity, tone, and luminosity
• Strengthens the skin's barrier integrity and epidermal resilience
• Activates cellular repair and improves intercellular communication
• No irritation. Safe for sensitive skin. Suitable for all skin types.

Clinically Measured. 42 Days. No Irritation.
Tested using advanced reconstructed human skin models designed to replicate human biological response. Compared to traditional animal-derived PDRN systems, the Vegan Dual PDRN Complex in DNA-42 demonstrates:

+266% Acceleration in visible cellular repair.
+200% Increase in collagen synthesis
+180% Acceleration in epidermal renewal
+115% Enhancement in fibroblast vitality
+111% Strengthening of visible skin resilience
+90% Improvement in intercellular communication
8.2 years Skin age reversal with Decrease in visible wrinkle depth vs. baseline (independent analysis, 42 days)

Day 1: Deep hydration and immediately refined texture. Skin feels plumped and prepared.

Day 14: Improved elasticity and smoother surface appearance. Lines appear softened.

Day 42: Visibly lifted contours. Increased dermal density. Softened expression lines. Strengthened barrier integrity. Skin appears up to 8 years younger.

Vegan PDRN Complex — Sodium DNA (Rice-Derived) + Hydrolyzed DNA (Barley-Derived): A plant-derived evolution of polydeoxyribonucleotide technology, clinically shown to outperform traditional animal-derived PDRN in fibroblast stimulation, collagen synthesis, and epidermal
renewal rate. This is not an ethical substitute for legacy technology. It is a clinically superior advancement of regenerative DNA science, delivering +200% increase in collagen synthesis and +266% acceleration in cellular repair vs. legacy formulations.

Plant Exosome Delivery Technology — Lycium Barbarum Callus Culture Extract (Phytocelltec™): Stem cell–derived phospholipid vesicle structures that enhance cellular communication and deepen the penetration of high molecular weight actives, including Vegan PDRN. The same delivery mechanism at the forefront of aesthetic dermatology, now available in a topical serum. Optimizes performance at a cellular level, ensuring repair signals reach the dermis where structural renewal begins.

Pro-Scaffolding Peptide Architecture — Acetyl Hexapeptide-8 + Palmitoyl Tripeptide-5: Acetyl Hexapeptide-8 reduces the appearance of expression lines through neuromodulating signaling mechanisms. Palmitoyl Tripeptide-5 activates TGF-beta pathways associated with collagen production and extracellular matrix reinforcement. Together, they support visible smoothing while strengthening dermal architecture at depth.

Amalfi Marine Biomimetic Support Matrix — Hydrolyzed Algin, Hydrolyzed, Rhodophyceae Extract, Chondrus Crispus Extract, Plankton Extract, Mineral-Rich Sea Water:
A mineral and polysaccharide complex drawn from the bioactive-rich coastline of the Amalfi Coast, the ecological foundation of Amalfi Born Biotechnology™. Supports extracellular hydration, reinforces elasticity, improves barrier integrity, and provides glycosaminoglycan support for tensile skin resilience.

Ingredients: Aqua (Water), Glycerin, Acetyl Hexapeptide-8, Palmitoyl Tripeptide-5, Citrus Reticulata (Tangerine) Fruit Extract, Pistacia Lentiscus (Mastic) Gum, Sodium Hyaluronate, Saccharide Isomerate, Aloe Barbadensis Leaf Extract, Helianthus Annuus (Sunflower) Sprout Extract, Hydrolyzed Algin, Plankton Extract, Sodium DNA, Hydrolyzed DNA, Lycium Barbarum Callus Culture Extract, Niacinamide, Chondrus Crispus Extract, Hydrolyzed Rhodophyceae Extract, Maris Aqua (Sea Water), Lecithin, Maltodextrin, Sucrose, Propanediol, Pentylene Glycol, Butylene Glycol, Phenethyl Alcohol, Glyceryl Caprylate, Glyceryl Caprate.

Doesn't Contain: Parabens, phthalates, sulfates, hydroquinone, formaldehyde, ethanolamines (MEA/DEA/TEA), BHA/BHT, triclosan/triclocarban, petrolatum, silicones, synthetic fragrance, artificial colors and plastic beads. Gluten free. Certified vegan and cruelty-free. Made in the USA.