Repair the Biology. Reverse the Damage. Reclaim Your Skin.
A physician-formulated regenerative serum that visibly lifts, densifies, and restores skin not by masking the signs of aging, but by activating the biological pathways responsible for structural renewal.
Long before "longevity skincare" became a trend, Clark's Botanicals was studying the cellular resilience mechanisms of the Amalfi Coast, one of the world's most biodiverse and protected coastal ecosystems, and translating them into measurable pathways for human skin. In this uniquely protected environment, botanicals and marine organisms thrive under constant environmental stress. DNA-42 captures the science behind that survival.
DNA-42 Clinicalift™ Serum is the first expression of Amalfi Born Biotechnology™, and the first topical serum to combine plant-derived exosome delivery technology with a Vegan PDRN regenerative complex. Together, they ensure that repair signals reach the dermal cells where visible renewal truly begins. Polydeoxyribonucleotide (PDRN) has long been studied in regenerative dermatology historically sourced from animal tissue.
DNA-42 advances this science entirely: our plant-derived Vegan PDRN complex, drawn from rice and barley, is clinically shown to outperform legacy animal-derived formulations in collagen synthesis, fibroblast vitality, and epidermal renewal. This is not an ethical compromise. It is a clinically superior evolution. The result is a serum that works with your skin's biology not against it. Skin appears smoother, clearer, and more luminous not because something has been erased, but because the skin's own structural vitality has been rebuilt.
Your skin's been keeping score. DNA-42 is here to settle it.
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30-DAY MONEY GUARANTEE We understand that sometimes an item that was purchased is not right for you. You have 30 days to return it and receive a refund. |
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CLINICALLY PROVEN Our products have been tested and proven to provide noticeable and satisfying results. |
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VEGAN AND NATURAL We are dedicated to delivering the purest and most natural ingredients for your skincare needs. |
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United States |
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Condition | Transit time | Price |
| Economy | 5 to 8 business days |
$5.00 USD |
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United Kingdom |
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Condition | Price |
| International Shipping | $100.00 and up |
$25.00 USD |
| International Shipping | $0.00–$99.99 |
$35.00 USD |
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Canada |
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Rate name |
Condition | Price |
| International Shipping | $0.00–$99.99 |
$35.00 USD |
| International Shipping | $100.00–$199.99 |
$15.00 USD |
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Rest of World |
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Condition | Price |
| International Shipping | — |
$35.00 USD |
Multiple addresses
At this time, we do not ship to more than one address per order.
Sales Tax
We are required by law to apply sales tax to orders (including shipping & handling) for the following states: NJ, NY, PA, TX.
Full Returns within 30 days for Domestic Orders on ClarksBotanicals.com: We understand that skincare is a personal purchase. Sometimes an item that was purchased is not right for you. Please email cs@clarksbotanicals.com for a pre-paid shipping label for your return and we will issue a full refund to your original form of payment.
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Clinical results
In 42 days
8
years younger appearance
15.3%
less wrinkle depth
In 56 days
11%
less wrinkle depth vs placebo
+6%
more skin density
Visible Improvement of Aging Signs After 42 days
Before
After
Amalfi Born Biotechnology™
Overall rating: 4.875 / 5 from 8 reviews.
Review topics: [].
"Although I have not experienced the "younger by 8 years" effect I still enjoy this serum. A little goea a long way! It is very spreadable, only need about 3 drops, presses in to the skin nicely and is absorbed within a minute. No issues with pilling when I layer hydrator and spf on top. Very thin consistency, and it appears to provide medium level hydration. This is my first experience with pdrn and plant exosomes and so far it's all positive!"
"I have been using DNA-42 for a little over a month. My skin feels softer and I think some of the fine lines are disappearing. I am 75 so although I would like a miracle…I will be happy with small improvements. I am ordering another bottle and hope that with continued use I will see more improvements!"
"Thought I would try this before my 50th high school reunion. After a couple of weeks I noticed that the droopy pouches under my eyes were gone. Not just improved-GONE. I was not expecting such drastic results!"
"I am 54 years old and have been using Clarks Botanicals products for several years. I just recently started using DNA-42. It feels good on my skin and I am anxious to see the effect after using it for a couple months. I am very happy with the products I have used for years so I have faith that this product will also become a staple in my routine:) Retinol Rescue, Marine cream, jasmine cream an a couple others are staples I currently use:)"
"Products never disappoint. Best out there. Thank you, and keep yo the good work!!!"
"Very impressive serum. I have been using for a week and my wrinkles are less noticeable already."
"Love how my skin feels after using this yummy serum"
"This stuff is the lightest most effective serum. Really. One squeeze (generous pearl sized) does my full face including my eyelids and neck, and I put the extra on my hands. It looks like 1 bottle is lasting 2 months and I use it 1-2x a day (usually 2x). It sinks right in and never bothers my eyes. I think my lashes are fuller and fall out less. As for my skin- I’m getting took for 15-20 years younger by stangers or people i just met…I used to get gueses 10 years of so younger but this is next level. My skin feels full and young- its like “ I remember when my neck was like this!” I’ve been using it for 6 weeks and I can’t wait to see longer term results. If the price is a lot for you, I’d say 1) use a mist first 2) use it once a day. Its like water and spreads like a dream, and its all you need. I love other products of theirs, but if you can only do one thing do this ."
